diff --git a/src/wp-admin/css/list-tables.css b/src/wp-admin/css/list-tables.css
index f6105ad5a59fb..6cc8c04701422 100644
--- a/src/wp-admin/css/list-tables.css
+++ b/src/wp-admin/css/list-tables.css
@@ -1458,7 +1458,6 @@ ul.cat-checklist input[name="post_category[]"]:indeterminate::before {
 	margin: 0 5px 0 -2px;
 	-webkit-font-smoothing: antialiased;
 	-moz-osx-font-smoothing: grayscale;
-	vertical-align: top;
 }
 
 .plugin-card .updating-message::before {
@@ -1483,6 +1482,7 @@ ul.cat-checklist input[name="post_category[]"]:indeterminate::before {
 	content: "\f147" / "";
 }
 
+.plugin-card .update-now::before,
 .plugin-card .updated-message::before,
 .plugin-card .updating-message::before {
 	line-height: 1;
@@ -1547,9 +1547,17 @@ ul.cat-checklist input[name="post_category[]"]:indeterminate::before {
 }
 
 .plugin-card-top {
+	display: grid;
+	grid-template-columns: 128px minmax(0, 1fr);
+	grid-template-rows: 1fr auto;
+	grid-template-areas:
+		"icon info"
+		"actions actions";
+	column-gap: 24px;
+	row-gap: 8px;
 	position: relative;
 	padding: 16px;
-	min-height: 135px;
+	flex: 1 1 auto;
 }
 
 div.action-links,
@@ -1558,32 +1566,37 @@ div.action-links,
 }
 
 .plugin-card h3 {
-	margin: 0 12px 16px 0;
+	margin: 0 0 16px;
 	font-size: 18px;
 	line-height: 1.3;
 }
 
-.plugin-card .desc {
-	margin-inline: 0;
+.plugin-card .plugin-icon {
+	grid-area: icon;
+	width: 128px;
+	height: 128px;
 }
 
-.plugin-card .name,
-.plugin-card .desc > p {
-	margin-left: 148px;
+/* Stretch the title link over the icon so clicking the icon opens the details modal. */
+.plugin-card .name a::after {
+	content: "";
+	position: absolute;
+	inset-block-start: 16px;
+	inset-inline-start: 16px;
+	width: 128px;
+	height: 128px;
 }
 
-@media (min-width: 1101px) {
-	.plugin-card .name,
-	.plugin-card .desc > p {
-		margin-right: 128px;
-	}
+.plugin-card-info {
+	grid-area: info;
+	display: flex;
+	flex-direction: column;
 }
 
-@media (min-width: 481px) and (max-width: 781px) {
-	.plugin-card .name,
-	.plugin-card .desc > p {
-		margin-right: 128px;
-	}
+.plugin-card .action-links {
+	grid-area: actions;
+	padding-top: 16px;
+	border-top: 1px solid rgba(0, 0, 0, 0.1);
 }
 
 .plugin-card .column-description {
@@ -1646,26 +1659,18 @@ div.action-links,
 	margin-top: 1em;
 }
 
-.plugin-card .action-links {
-	position: absolute;
-	top: 20px;
-	right: 20px;
-	width: 120px;
-}
-
 .plugin-action-buttons {
-	clear: right;
-	float: right;
-	margin-bottom: 1em;
-	text-align: right;
+	display: flex;
+	flex-wrap: wrap;
+	align-items: center;
+	gap: 8px 16px;
 }
 
 .plugin-action-buttons li {
-	margin-bottom: 10px;
+	margin: 0;
 }
 
 .plugin-card-bottom {
-	clear: both;
 	padding: 16px;
 	background-color: #f6f7f7;
 	border-top: 1px solid rgba(0, 0, 0, 0.1);
@@ -1745,15 +1750,6 @@ div.action-links,
 	margin: 20px 20px 0;
 }
 
-.plugin-card .plugin-icon {
-	position: absolute;
-	top: 20px;
-	left: 20px;
-	width: 128px;
-	height: 128px;
-	margin: 0 20px 20px 0;
-}
-
 .no-plugin-results {
 	color: #646970; /* same as no themes and no media */
 	font-size: 18px;
@@ -1792,42 +1788,6 @@ div.action-links,
 /* =Media Queries
 -------------------------------------------------------------- */
 
-@media screen and (max-width: 1100px) and (min-width: 782px), (max-width: 480px) {
-	.plugin-card .action-links {
-		position: static;
-		margin-left: 148px;
-		width: auto;
-	}
-
-	.plugin-action-buttons {
-		float: none;
-		margin: 1em 0 0;
-		text-align: left;
-	}
-
-	.plugin-action-buttons li {
-		display: inline-block;
-		vertical-align: middle;
-	}
-
-	.plugin-action-buttons li .button {
-		margin-right: 20px;
-	}
-
-	.plugin-card h3 {
-		margin-right: 24px;
-	}
-
-	.plugin-card .name,
-	.plugin-card .desc {
-		margin-right: 0;
-	}
-
-	.plugin-card .desc p:first-of-type {
-		margin-top: 0;
-	}
-}
-
 @media screen and (max-width: 782px) {
 	/* WP List Table Options & Filters */
 	.tablenav {
diff --git a/src/wp-admin/includes/class-wp-plugin-install-list-table.php b/src/wp-admin/includes/class-wp-plugin-install-list-table.php
index 3f6d2a104d099..0c4e0af729cd4 100644
--- a/src/wp-admin/includes/class-wp-plugin-install-list-table.php
+++ b/src/wp-admin/includes/class-wp-plugin-install-list-table.php
@@ -742,13 +742,19 @@ public function display_rows() {
 			}
 			?>
 			<div class="plugin-card-top">
-				<div class="name column-name">
-					<h3>
-						<a href="<?php echo esc_url( $details_link ); ?>" class="thickbox open-plugin-details-modal">
-						<?php echo $title; ?>
-						<img src="<?php echo esc_url( $plugin_icon_url ); ?>" class="plugin-icon" alt="" />
-						</a>
-					</h3>
+				<img src="<?php echo esc_url( $plugin_icon_url ); ?>" class="plugin-icon" alt="" aria-hidden="true" />
+				<div class="plugin-card-info">
+					<div class="name column-name">
+						<h3>
+							<a href="<?php echo esc_url( $details_link ); ?>" class="thickbox open-plugin-details-modal">
+							<?php echo $title; ?>
+							</a>
+						</h3>
+					</div>
+					<div class="desc column-description">
+						<p><?php echo $description; ?></p>
+						<p class="authors"><?php echo $author; ?></p>
+					</div>
 				</div>
 				<div class="action-links">
 					<?php
@@ -757,10 +763,6 @@ public function display_rows() {
 					}
 					?>
 				</div>
-				<div class="desc column-description">
-					<p><?php echo $description; ?></p>
-					<p class="authors"><?php echo $author; ?></p>
-				</div>
 			</div>
 			<?php
 			$dependencies_notice = $this->get_dependencies_notice( $plugin );