diff --git a/src/material/core/option/option-parent.ts b/src/material/core/option/option-parent.ts
index 8df8908f35a5..82d1e0e8c00e 100644
--- a/src/material/core/option/option-parent.ts
+++ b/src/material/core/option/option-parent.ts
@@ -15,6 +15,7 @@ import {InjectionToken, Signal} from '@angular/core';
  */
 export interface MatOptionParentComponent {
   disableRipple?: boolean | Signal<boolean>;
+  disableOptions?: boolean;
   multiple?: boolean;
   inertGroups?: boolean;
   hideSingleSelectionIndicator?: boolean;
diff --git a/src/material/core/option/option.ts b/src/material/core/option/option.ts
index a4a893b25489..8e261da06278 100644
--- a/src/material/core/option/option.ts
+++ b/src/material/core/option/option.ts
@@ -241,7 +241,7 @@ export class MatOption<T = any> implements FocusableOption, AfterViewChecked, On
    * determine if the select's view -> model callback should be invoked.`
    */
   _selectViaInteraction(): void {
-    if (!this.disabled) {
+    if (!this.disabled && !this._parent?.disableOptions) {
       this._selected = this.multiple ? !this._selected : true;
       this._changeDetectorRef.markForCheck();
       this._emitSelectionChangeEvent(true);
diff --git a/src/material/select/select.spec.ts b/src/material/select/select.spec.ts
index 9728ec2d78ac..ae407afa9f24 100644
--- a/src/material/select/select.spec.ts
+++ b/src/material/select/select.spec.ts
@@ -1932,6 +1932,22 @@ describe('MatSelect', () => {
         expect(trigger.textContent!.trim()).toBe('PIZZA');
       });
 
+      it('should not select an option when disabled while open', () => {
+        fixture.componentInstance.control.setValue('pizza-1');
+        fixture.detectChanges();
+        trigger.click();
+        fixture.detectChanges();
+        const selectionChange = jasmine.createSpy('selectionChange');
+        fixture.componentInstance.select.selectionChange.subscribe(selectionChange);
+        fixture.componentInstance.control.disable({emitEvent: false});
+        fixture.detectChanges();
+        const option = getOverlayHost(fixture)!.querySelector('mat-option') as HTMLElement;
+        option.click();
+        fixture.detectChanges();
+        expect(fixture.componentInstance.control.value).toBe('pizza-1');
+        expect(selectionChange).not.toHaveBeenCalled();
+      });
+
       it('should not select disabled options', () => {
         trigger.click();
         fixture.detectChanges();
diff --git a/src/material/select/select.ts b/src/material/select/select.ts
index 59415b689663..57cdbde6eaa4 100644
--- a/src/material/select/select.ts
+++ b/src/material/select/select.ts
@@ -387,6 +387,11 @@ export class MatSelect
   @Input({transform: booleanAttribute})
   disabled: boolean = false;
 
+  /** Whether options are disabled by the select. */
+  get disableOptions(): boolean {
+    return this.disabled;
+  }
+
   /** Whether ripples in the select are disabled. */
   @Input({transform: booleanAttribute})
   get disableRipple() {