diff --git a/master/custom/builders.py b/master/custom/builders.py
index f781c69c..c77aecd7 100644
--- a/master/custom/builders.py
+++ b/master/custom/builders.py
@@ -21,7 +21,7 @@
     UnixRefleakBuild,
     UnixNoGilBuild,
     UnixNoGilRefleakBuild,
-    MacOSAsanNoGilBuild,
+    MacOSIntelAsanNoGilBuild,
     ClangUnixBuild,
     ClangUbsanLinuxBuild,
     ClangUbsanFunctionLinuxBuild,
@@ -278,7 +278,7 @@ def generate_builderdefs(tags, entries):
     # macOS x86-64 clang
     ("x86-64 macOS", "billenstein-macos", UnixBuild),
     ("x86-64 MacOS Intel NoGIL", "itamaro-macos-intel-aws", UnixNoGilBuild),
-    ("x86-64 MacOS Intel ASAN NoGIL", "itamaro-macos-intel-aws", MacOSAsanNoGilBuild),
+    ("x86-64 MacOS Intel ASAN NoGIL", "itamaro-macos-intel-aws", MacOSIntelAsanNoGilBuild),
 
     # WASI
     ("wasm32-wasi", "bcannon-wasi", Wasm32WasiPreview1DebugBuild),
diff --git a/master/custom/factories.py b/master/custom/factories.py
index c5ce171e..255e1c7c 100644
--- a/master/custom/factories.py
+++ b/master/custom/factories.py
@@ -620,13 +620,14 @@ class MacOSArmWithBrewNoGilRefleakBuild(UnixNoGilRefleakBuild):
     ]
 
 
-class MacOSAsanNoGilBuild(UnixAsanNoGilBuild):
+class MacOSIntelAsanNoGilBuild(UnixAsanNoGilBuild):
+    # Intel (x86_64) Mac: Homebrew's prefix is /usr/local, not /opt/homebrew.
     buildersuffix = ".macos-with-brew.asan.nogil"
     configureFlags = UnixAsanNoGilBuild.configureFlags + [
-        "--with-openssl=/opt/homebrew/opt/openssl@3",
-        "CPPFLAGS=-I/opt/homebrew/include",
-        "LDFLAGS=-L/opt/homebrew/lib",
-        "PKG_CONFIG_PATH=/opt/homebrew/opt/tcl-tk@8/lib/pkgconfig",
+        "--with-openssl=/usr/local/opt/openssl@3",
+        "CPPFLAGS=-I/usr/local/include",
+        "LDFLAGS=-L/usr/local/lib",
+        "PKG_CONFIG_PATH=/usr/local/opt/tcl-tk@8/lib/pkgconfig",
     ]
     asan_options = 'detect_leaks=0:allocator_may_return_null=1:handle_segv=0'
     compile_environ = {'ASAN_OPTIONS': asan_options}