diff --git a/Lib/inspect.py b/Lib/inspect.py
index c52469e63861a22..45b7e47f05da7a1 100644
--- a/Lib/inspect.py
+++ b/Lib/inspect.py
@@ -1626,7 +1626,7 @@ def getframeinfo(frame, context=1):
         raise TypeError('{!r} is not a frame or traceback object'.format(frame))
 
     filename = getsourcefile(frame) or getfile(frame)
-    if context > 0:
+    if context > 0 and lineno is not None:
         start = lineno - 1 - context//2
         try:
             lines, lnum = findsource(frame)
diff --git a/Lib/test/test_inspect/test_inspect.py b/Lib/test/test_inspect/test_inspect.py
index df5843abfcb8753..e8f5d949a35fa72 100644
--- a/Lib/test/test_inspect/test_inspect.py
+++ b/Lib/test/test_inspect/test_inspect.py
@@ -846,6 +846,39 @@ def test_getframeinfo_get_first_line(self):
         self.assertEqual(frame_info.code_context[0], "# line 1\n")
         self.assertEqual(frame_info.code_context[1], "'A module docstring.'\n")
 
+    def test_getframeinfo_no_lineno(self):
+        # gh-89726: some instructions carry no line number, so a frame
+        # stopped on one has f_lineno set to None.  getframeinfo() must
+        # report that rather than failing.
+        def f():
+            try:
+                raise ValueError
+            except ValueError:
+                pass
+
+        infos = []
+
+        def trace(frame, event, arg):
+            if frame.f_code is f.__code__ and frame.f_lineno is None:
+                infos.append(inspect.getframeinfo(frame))
+            frame.f_trace_opcodes = True
+            return trace
+
+        old_trace = sys.gettrace()
+        sys.settrace(trace)
+        try:
+            f()
+        finally:
+            sys.settrace(old_trace)
+
+        self.assertTrue(infos, 'no frame with f_lineno set to None')
+        for info in infos:
+            with self.subTest(info=info):
+                self.assertIsNone(info.lineno)
+                self.assertIsNone(info.code_context)
+                self.assertIsNone(info.index)
+                self.assertEqual(info.function, 'f')
+
     def test_getsource(self):
         self.assertSourceEqual(git.abuse, 29, 39)
         self.assertSourceEqual(mod.StupidGit, 21, 51)
diff --git a/Misc/NEWS.d/next/Library/2022-03-22-10-16-11.bpo-45563.o-oP2m.rst b/Misc/NEWS.d/next/Library/2022-03-22-10-16-11.bpo-45563.o-oP2m.rst
new file mode 100644
index 000000000000000..aa32e5e1e76028d
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2022-03-22-10-16-11.bpo-45563.o-oP2m.rst
@@ -0,0 +1,4 @@
+:func:`inspect.getframeinfo` no longer raises :exc:`TypeError` for a frame
+stopped on an instruction that carries no line number, such as while tracing
+opcodes.  ``lineno``, ``code_context`` and ``index`` are reported as ``None``
+instead.